The structure of the TSH-R, a glycoprotein, is shown in Fig. 17.10 in diagrammatic form.
TSH and TSH-R antibodies in patients with Graves' disease bind to the extracellular domain of the receptor, and by acting via the receptor-linked G-binding protein stimulate cyclic AMP production and subsequent thyroid hormone synthesis. Modified from McGregor (1992) by courtesy of Oxford University Press.
